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The future of clinical testing of the general trend: “centralization” or “to the center”? –POCT articles

Shanghai Tendrew/2017-06-14/Views: 1,006 Views

       The Ninth National Conference on Clinical Laboratory Management (NCCLab2017) was successfully concluded on June 5. Three days down, as nowadays the hottest medical concept, "precision medical" to become the conference report was mentioned the most frequently noun.
Mass spectrometry (MS) technology and point-of-care testing (POCT) technology as two new clinical detection technology, in the field of precision medical have a wide range of important applications. Therefore, the General Assembly, respectively, the establishment of the theme venue for MS and POCT for specialized discussions, which also makes MS and POCT become the two most heated theme of the conference. MS and POCT represent the two trends of "centralization" and "de-centralization" of clinical testing in the future. So the question came, "centralization" and "to the center", the two who will become the future trend of clinical testing it?

In the last article, "the future of clinical testing of the general trend:" centralization "or" to the center " - (on): MS articles ", the author focuses on the application of MS in clinical testing. In this article, the author will focus on the application of POCT in clinical testing, the existing problems and development trends.

       There are many foreign POCT related terms, such as bedside testing, near-patient testing, physicians office testing, home use testing, extra-laboratory Testing (outside the inspection of the test) and decentralized testing (decentralized test) and so on. With the continuous development of this field, these terms have been unable to summarize the meaning of POCT.

       POCT, point-of-care testing, by the Chinese Medical Equipment Association POCT Equipment Technology Committee on a number of expert arguments based on the unified naming, and its definition: at the sampling site, the use of portable analysis Equipment and supporting reagents quickly get a test result of a test. POCT does not require specialized clinical testing services, portability and timeliness is its greatest advantage.

       In recent years, the rapid development of POCT has benefited from the continuous breakthrough of biochip technology based on molecular biology, cell biology and dry chemistry. In a sense, in today's clinical testing applications, said the bio-chip is POCT is not an exaggeration. Biochip is divided into gene chip, protein chip, cell chip and chip lab. Because of the development of high-tech and the progress of medical science, as well as the efficient and fast-paced work style, combined with the most popular precision medicine, individual diagnosis and treatment concept, making the experimental equipment miniaturization, simple operation, POCT more and more people have been favored.
At present, some international giants such as DANAHER, ROCHE, BIOMERIEUX, ABBOTT and so have the force POCT, the international development of POCT was "to the center" trend. In the report titled "POCT Molecular Diagnostic Trends", CEO of Kayu Di Biotech Co., Ltd., CEO Li Xiang, gave a detailed explanation of the one-step "nucleic acid detection platform (with real-time fluorescence quantitative PCR) POCT technology of the great changes.

        The traditional PCR method must first be used to crack, adsorb, rinse, elute and so on, and then the sample can be detected. The "one-step" nucleic acid detection is not pre-treated and can be added directly. Takes 60-90 minutes, compared to the traditional PCR method frequently 3-4 hours, both to simplify the operation and save a lot of time. In addition, the "one-step" nucleic acid detection sample with less, only the traditional nucleic acid detection method 1/10.
        POCT is widely used in clinical detection of diabetes monitoring, urine dry chemical analysis, coagulation index detection, myocardial marker detection, tumor marker detection, infectious disease chlamydia detection, rapid screening of HIV, blood chemical composition analysis Project, sensitivity and specificity are superior to traditional methods, coupled with its "decentralization" trend, excellent portability and timeliness, and is of great significance to individualized precision diagnosis and treatment.